Letter to MBE Evolution of the Isd11/IscS complex reveals a single α- proteobacterial endosymbiosis for all eukaryotes
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منابع مشابه
Mitochondrial type iron-sulfur cluster assembly in the amitochondriate eukaryotes Trichomonas vaginalis and Giardia intestinalis, as indicated by the phylogeny of IscS.
Pyridoxal-5'-phosphate-dependent cysteine desulfurase (IscS) is an essential enzyme in the assembly of FeS clusters in bacteria as well as in the mitochondria of eukaryotes. Although FeS proteins are particularly important for the energy metabolism of amitochondrial anaerobic eukaryotes, there is no information about FeS cluster formation in these organisms. We identified and sequenced two IscS...
متن کاملThe Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS
The eukaryotic protein Isd11 is a chaperone that binds and stabilizes the central component of the essential metabolic pathway responsible for formation of iron-sulfur clusters in mitochondria, the desulfurase Nfs1. Little is known about the exact role of Isd11. Here, we show that human Isd11 (ISD11) is a helical protein which exists in solution as an equilibrium between monomer, dimeric and te...
متن کاملHuman ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis.
The LYR family consists of proteins of diverse functions that contain the conserved tripeptide 'LYR' near the N-terminus, and it includes Isd11, which was previously observed to have an important role in iron-sulfur (Fe-S) cluster biogenesis in Saccharomyces cerevisiae. Here, we have cloned and characterized human ISD11 and shown that human ISD11 forms a stable complex in vivo with the human cy...
متن کاملTrading Places—Switching Frataxin Function by a Single Amino Acid Substitution within the [Fe-S] Cluster Assembly Scaffold
Simple inorganic structures comprised of iron and sulfur are called [Fe-S] clusters. They likely represent one of the earliest prosthetic groups associated with the emergence of life on earth and continue to have essential roles in sustaining many metabolic processes in almost all existing life forms. For example, proteins that contain one or more [Fe-S] clusters, generally referred to as [Fe-S...
متن کاملConflict and cooperation in eukaryogenesis: implications for the timing of endosymbiosis and the evolution of sex.
Roughly 1.5-2.0 Gya, the eukaryotic cell evolved from an endosymbiosis of an archaeal host and proteobacterial symbionts. The timing of this endosymbiosis relative to the evolution of eukaryotic features remains subject to considerable debate, yet the evolutionary process itself constrains the timing of these events. Endosymbiosis entailed levels-of-selection conflicts, and mechanisms of confli...
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تاریخ انتشار 2006